An excerpt of Bhaktivedanta Swami Prabhupada’s lecture at Harvard University on 24 December 1969. Link to download the full speech [pdf file] is at the end.
This materialistic life means full of anxiety always. And spiritual life means without this anxiety. Just the opposite. Brahma-bhutah prasannatma. And what is the symptom of being joyful? That is also stated: na socati na kanksati. There is no lamentation or loss, and there is no hankering for gain. Everyone in this material world is hankering after some gain. And if you have got some gain, if it is lost, then he’s lamenting, “Oh, I have lost so much.” So these two business… Hankering, when we do not possess, we hanker. And when we possess, it is lost. Because everything… The material waves are such that whatever we possess, we shall lose it. We have got this nice body, one day we have to lose it. Everything. You possess and lose, possess and lose. Therefore the…, punah punas car…, the same thing repeatedly: gaining and losing, and lamenting and hankering, lamenting and hankering. This is the position of material life.
Download the complete speech here – http://www.iskcon-coimbatore.org/iskconcbe/Srila_Prabhupada_at_Harvard.pdf